Hippocampal overexpression of mutant creb blocks long-term, but not short-term memory for a socially transmitted food preference.

@article{Brightwell2005HippocampalOO,
  title={Hippocampal overexpression of mutant creb blocks long-term, but not short-term memory for a socially transmitted food preference.},
  author={Jennifer J. Brightwell and Clayton A. Smith and Renee A Countryman and Rachael Lee Neve and Paul J. Colombo},
  journal={Learning & memory},
  year={2005},
  volume={12 1},
  pages={12-7}
}
Phosphorylation of the transcription factor CREB on Ser133 is implicated in the establishment of long-term memory for hippocampus-dependent tasks, including spatial learning and contextual fear conditioning. We reported previously that training on a hippocampus-dependent social transmission of food preference (STFP) task increases CREB phosphorylation in the hippocampus of trained rats in comparisons with controls. In the current study, we tested the hypothesis that CREB function is necessary… CONTINUE READING

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