Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol.

  title={Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol.},
  author={Guy C. K. Chan and Thomas R. Hinds and Soren Impey and Daniel R Storm},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 14},
Marijuana consumption elicits diverse physiological and psychological effects in humans, including memory loss. Here we report that Delta9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, is toxic for hippocampal neurons. Treatment of cultured neurons or hippocampal slices with THC caused shrinkage of neuronal cell bodies and nuclei as well as genomic DNA strand breaks, hallmarks of neuronal apoptosis. Neuron death induced by THC was inhibited by nonsteroidal anti… CONTINUE READING