Hippocampal neuronal loss, decreased GFAP immunoreactivity and cognitive impairment following experimental intoxication of rats with aluminum citrate

@article{Silva2013HippocampalNL,
  title={Hippocampal neuronal loss, decreased GFAP immunoreactivity and cognitive impairment following experimental intoxication of rats with aluminum citrate},
  author={A. V. Fischer da Silva and Maria Socorro S. Aguiar and Odemir S. Carvalho and Luana de Nazar{\'e} Silva Santana and Edna C.S. Franco and Rafael Rodrigues Lima and Natalino Valente M. de Siqueira and Romulo Augusto Feio and L{\'i}lian Rosana Ferreira Faro and Walace Gomes-Leal},
  journal={Brain Research},
  year={2013},
  volume={1491},
  pages={23-33}
}
Aluminum (Al) is a neurotoxic agent with deleterious actions on cognitive processes. Nevertheless, few studies have investigated the neuropathological effects underlying the Al-induced cognitive impairment. We have explored the effects of acute Al citrate intoxication on both hippocampal morphology and mnemonic processes in rodents. Adult male Wistar rats were intoxicated with a daily dose of Al citrate (320 mg/kg) during 4 days by gavage. Animals were perfused at 8 (G2), 17 (G3) and 31 days… CONTINUE READING

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