Hippocampal neurogenesis protects against cocaine-primed relapse.

  title={Hippocampal neurogenesis protects against cocaine-primed relapse.},
  author={Olivier Deschaux and Leandro F Vendruscolo and Joel E. Schlosburg and Luis Diaz-Aguilar and Clara J. Yuan and Jeffery C. Sobieraj and Olivier George and George F. Koob and Chitra D Mandyam},
  journal={Addiction biology},
  volume={19 4},
Accumulating evidence demonstrates a functional role for the hippocampus in mediating relapse to cocaine-seeking behavior and extinction-induced inhibition of cocaine seeking, and dentate gyrus neurogenesis in the hippocampus may have a role. Here, we tested the hypothesis that disruption of normal hippocampal activity during extinction alters relapse to cocaine-seeking behavior as a function of dentate gyrus neurogenesis. Adult rats were trained to self-administer cocaine on a fixed-ratio… CONTINUE READING
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