Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

@article{Meshi2006HippocampalNI,
  title={Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment},
  author={Dar Meshi and Michael R. Drew and Michael D. Saxe and Mark S Ansorge and Denis J David and Luca Santarelli and Chariklia Malapani and Holly M Moore and Ren{\'e} Hen},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={729-731}
}
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these… 
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It is found that mice with ablation of new neurons in the dentate gyrus exhibit reduced anxiety during the dark cycle and glucocorticoid receptor target genes and neuronal activity markers showed reduced expression after stress in neurogenesis-deficient mice, suggesting that newborn neurons inThe hippocampus are involved in sensing and eliciting an appropriate response to stress.
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The relative contribution of adult neurogenesis and dendritic/synaptic remodeling of existing neurons to hippocampal plasticity is discussed.
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TLDR
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