Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

@article{Meshi2006HippocampalNI,
  title={Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment},
  author={Dar Meshi and Michael R. Drew and Michael D. Saxe and Mark S Ansorge and Denis J David and Luca Santarelli and Chariklia Malapani and Holly M Moore and Ren{\'e} Hen},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={729-731}
}
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these… 
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