Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

  title={Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment},
  author={Dar Meshi and Michael R. Drew and Michael D. Saxe and Mark S Ansorge and Denis J David and Luca Santarelli and Chariklia Malapani and Holly M Moore and Ren{\'e} Hen},
  journal={Nature Neuroscience},
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these… 
Environmental enrichment and neurogenesis: from mice to humans
The role of adult hippocampal neurogenesis in brain health and disease
A possible link between the physiological functions of adult-born neurons and their roles in pathological conditions is reviewed.
Paradoxical influence of hippocampal neurogenesis on working memory
To explore the function of adult hippocampal neurogenesis, we ablated cell proliferation by using two independent and complementary methods: (i) a focal hippocampal irradiation and (ii) an inducible
Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle
It is found that mice with ablation of new neurons in the dentate gyrus exhibit reduced anxiety during the dark cycle and glucocorticoid receptor target genes and neuronal activity markers showed reduced expression after stress in neurogenesis-deficient mice, suggesting that newborn neurons inThe hippocampus are involved in sensing and eliciting an appropriate response to stress.
Adult Neurogenesis and Dendritic Remodeling in Hippocampal Plasticity: Which One is more Important?
  • S. Yau, K. So
  • Biology, Psychology
    Cell transplantation
  • 2014
The relative contribution of adult neurogenesis and dendritic/synaptic remodeling of existing neurons to hippocampal plasticity is discussed.


Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
The results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal‐dependent memories.
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment
It is established that newborn cells in the dentate gyrus contribute to the expression of the promnesic effects of behavioural enrichment, and they provide further support for the idea that adult‐generated neurons participate in modulating memory function.
Neural consequences of enviromental enrichment
This article focuses on the neuronal changes that occur in response to complex stimulation by an enriched environment and emphasizes the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning.
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentates gyrus.
Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory.
It is shown that adult rats housed in an enriched environment show improved performance in a spatial learning test, suggesting that environmental cues can enhance neurogenesis in the adult hippocampal region, which is associated with improved spatial memory.
Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus
The behavioural results obtained following subchronic treatment with high doses of MAM in adulthood must be interpreted with extreme caution because of the small residual number of new cells produced following MAM treatment.