Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia

@article{Lai2010HippocampalNT,
  title={Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia},
  author={Mitchell Kim Peng Lai and Christopher P. Chen and Tony Hope and Margaret M. Esiri},
  journal={NeuroReport},
  year={2010},
  volume={21},
  pages={1111–1115}
}
Neuropsychiatric behaviours occur frequently in Alzheimer's disease and other dementias and are thought to arise from the neurodegenerative process. However, it is unclear whether neurodegenerative changes in the hippocampus are associated with neuropsychiatric behaviours such as aggression. In this study, semiquantitative measurements of cell loss, atrophy, neuritic plaque and neurofibrillary tangle load in the postmortem hippocampus were taken for dementia patients, prospectively assessed for… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease
TLDR
It is suggested that agitation and aberrant motor behavior are correlates of greater NFT pathology in the orbitofrontal cortex in AD, whereas increasing apathy may relate to greater N FT burden in the anterior cingulate. Expand
Cholinergic deficits contribute to behavioral disturbance in patients with dementia
TLDR
Disturbance of the cholinergic system may underlie both cognitive and some noncognitive behavioral changes in dementia, providing a basis for rational therapy. Expand
Altered glutamate neurotransmission and behaviour in dementia: evidence from studies of memantine.
  • P. Francis
  • Medicine
  • Current molecular pharmacology
  • 2009
TLDR
The frontal and cingulate cortices--specifically, the formation of neurofibrillary tangles in glutamatergic pyramidal neurones of these areas--are proposed as regional substrates of these behaviours. Expand
Presynaptic Serotonergic Markers in Community‐Acquired Cases of Alzheimer's Disease: Correlations with Depression and Neuroleptic Medication
TLDR
Alzheimer patients who had persistent depressive symptoms during life had significantly fewer serotonin uptake sites in both cortical areas compared with Alzheimer patients without these symptoms and Alzheimer patients who were receiving chronic neuroleptic medication had significantly lower concentrations of serotonin in frontal cortex and 5‐hydroxyindoleacetic acid in temporal cortex. Expand
Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study.
TLDR
The natural history of behaviour changes in Alzheimer's disease shows great individual variation although some changes tend to follow a recognisable sequence, and some changes can occur at almost any time in the course of dementia. Expand
Alzheimer's disease
TLDR
Advances in understanding the pathogenetic cascade of events that characterize AD provide a framework for early detection and therapeutic interventions, including transmitter replacement therapies, antioxidants, anti-inflammatory agents, estrogens, nerve growth factor, and drugs that prevent amyloid formation in the brain. Expand
Neuropathological stageing of Alzheimer-related changes
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages. Expand
Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease
TLDR
The present study investigated the state of 5-HT(1A) receptors in the postmortem neocortex of 33 AD patients prospectively assessed for cognition and behavioral symptoms, together with 20 matched controls, by saturation [(3)H]8-OH-DPAT binding assays, and found that 5- HT(1a) receptor binding affinity and density were unchanged in the overall AD group compared with controls. Expand
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study.
TLDR
These are the first population-based estimates for neuropsychiatric symptoms in MCI, indicating a high prevalence associated with this condition as well. Expand
The spectrum of behavioral changes in Alzheimer's disease
TLDR
Agitation, dysphoria, apathy, and aberrant motor behavior were significantly correlated with cognitive impairment in patients with Alzheimer's disease compared with normal age-matched control subjects. Expand
...
1
2
3
...