Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.

  title={Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.},
  author={Karen E. Stevens and G Shiotsu and Larry Stein},
  journal={Brain research},
  volume={545 1-2},
Dependence on reinforcing chemicals is manifested when drug-seeking and drug-taking behaviors come to dominate the response repertoire. Clinical observations suggest that the craving and compulsive drug-seeking that characterize drug dependence are aroused by memories of the reinforcing drug experience. If so, a brain structure intimately associated with memory--the hippocampus--would be a plausible substrate for drug reinforcement effects. We report here that drug-naive rats rapidly learn to… CONTINUE READING

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