Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin.

@article{Okazaki1995HippocampalMF,
  title={Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin.},
  author={Maxine M. Okazaki and Debra A. Evenson and J. Victor Nadler},
  journal={The Journal of comparative neurology},
  year={1995},
  volume={352 4},
  pages={515-34}
}
In complex partial epilepsy and in animal models of epilepsy, hippocampal mossy fibers appear to develop recurrent collaterals that invade the dentate molecular layer. Mossy fiber collaterals have been proposed to subserve recurrent excitation by forming granule cell-granule cell synapses. This hypothesis was tested by visualizing dentate granule cells and their mossy fibers after terminal uptake and retrograde transport of biocytin. Labeling studies were performed with transverse slices of the… CONTINUE READING
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