Hippocampal morphometry in depressed patients and control subjects: relations to anxiety symptoms.

@article{Rusch2001HippocampalMI,
  title={Hippocampal morphometry in depressed patients and control subjects: relations to anxiety symptoms.},
  author={Brett D Rusch and Heather C. Abercrombie and Terrence R. Oakes and Stacey M. Schaefer and Richard J. Davidson},
  journal={Biological psychiatry},
  year={2001},
  volume={50 12},
  pages={960-4}
}
BACKGROUND Although it has been hypothesized that glucocorticoid hypersecretion in depressed patients leads to neuronal atrophy in the hippocampus, magnetic resonance imaging (MRI) -based morphometry studies of the hippocampus to date have produced mixed results. METHODS In our MRI study, hippocampal volumes were measured in 25 depressed patients (13 with melancholia and 12 without melancholia) and 15 control subjects. RESULTS No significant differences in hippocampus volumes were found… CONTINUE READING