Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target

@inproceedings{Shaltiel2011HippocampalMM,
  title={Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target},
  author={G. Shaltiel and M. El-Hewairy Hanan and Yochai Wolf and Shahar Barbash and Eugenia Kovalev and Shai Shoham and Hermona Soreq},
  booktitle={Brain Structure and Function},
  year={2011}
}
Diverse stress stimuli induce long-lasting cognitive deficits, but the underlying molecular mechanisms are still incompletely understood. Here, we report three different stress models demonstrating that stress-inducible increases in microRNA-132 (miR-132) and consequent decreases in its acetylcholinesterase (AChE) target are causally involved. In a mild model of predator scent-induced anxiety, we demonstrate long-lasting hippocampal elevation of miR-132, accompanied by and associated with… CONTINUE READING

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