Hippocampal loss of the GABAA receptor α1 subunit in patients with chronic pharmacoresistant epilepsies

Abstract

Alterations of gamma aminobutyric acid (GABA)-mediated neurotransmission have been implicated in the pathogenesis of epilepsies. Here we examine the distribution of the GABAA receptor in the hippocampus of 78 surgical specimens from patients with chronic pharmacoresistant focal epilepsies. The receptor was localized immunohistochemically with the monoclonal… (More)
DOI: 10.1007/BF00310375

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@article{Wolf1994HippocampalLO, title={Hippocampal loss of the GABAA receptor α1 subunit in patients with chronic pharmacoresistant epilepsies}, author={Helmut K. Wolf and Matthias Sp{\"a}nle and Marianne M{\"{u}ller and Christian Erich Elger and Johannes Schramm and Otmar Dieter Wiestler}, journal={Acta Neuropathologica}, year={1994}, volume={88}, pages={313-319} }