Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s disease

  title={Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s disease},
  author={Hisaaki Takahashi and Ivona Brasnjevic and Bart P. F. Rutten and Nicolien Van Der Kolk and Daniel P. Perl and Constantin Bouras and Harry W. M. Steinbusch and Christoph Schmitz and Patrick R. Hof and Dara L. Dickstein},
  journal={Brain Structure and Function},
Hippocampal atrophy and neuron loss are commonly found in Alzheimer’s disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not yet been properly assessed. Using quantitative stereologic methods, we analyzed the regional pattern of age-related loss of PV- and CR-immunoreactive (ir) neurons in the hippocampus of mice that carry M233T/L235P… CONTINUE READING


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