Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults.

@article{Putcha2011HippocampalHA,
  title={Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults.},
  author={Deepti Putcha and Michael Brickhouse and Kelly O'Keefe and Caroline Sullivan and Dorene Rentz and Gad A. Marshall and Brad C Dickerson and Reisa Sperling},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 48},
  pages={17680-8}
}
Alzheimer's disease (AD) is associated with functional and structural alterations in a distributed network of brain regions supporting memory and other cognitive domains. Functional abnormalities are present in mild cognitive impairment (MCI) with evidence of early hyperactivity in medial temporal lobe regions, followed by failure of hippocampal activation as dementia develops. Atrophy in a consistent set of cortical regions, the "cortical signature of AD," has been reported at the stage of… CONTINUE READING
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