Hippocampal gene expression induced by cold swim stress depends on sex and handling.

@article{Bohacek2015HippocampalGE,
  title={Hippocampal gene expression induced by cold swim stress depends on sex and handling.},
  author={Johannes Bohacek and Francesca Manuella and Martin Roszkowski and Isabelle M Mansuy},
  journal={Psychoneuroendocrinology},
  year={2015},
  volume={52},
  pages={1-12}
}
Stress-related disorders such as PTSD and depression are more prevalent in women than men. One reason for such discordance may be that brain regions involved in stress responses are more sensitive to stress in females. Here, we compared the effects of acute stress on gene transcription in the hippocampus of female and male mice, and also examined the involvement of two key stress-related hormones, corticosterone and corticotropin releasing hormone (Crh). Using quantitative reverse transcription… CONTINUE READING
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