Hippocampal epigenetic modification at the brain‐derived neurotrophic factor gene induced by an enriched environment

  title={Hippocampal epigenetic modification at the brain‐derived neurotrophic factor gene induced by an enriched environment},
  author={Naoko Kuzumaki and Daigo Ikegami and Rie Tamura and Nana Hareyama and Satoshi Imai and Michiko Narita and Kazuhiro Torigoe and Keiichi Niikura and Hideyuki Takeshima and Takayuki Ando and Katsuhide Igarashi and Jun Kanno and Toshikazu Ushijima and Tsutomu Suzuki and Minoru Narita},
Environmental enrichment is an experimental paradigm that increases brain‐derived neurotrophic factor (BDNF) gene expression accompanied by neurogenesis in the hippocampus of rodents. In the present study, we investigated whether an enriched environment could cause epigenetic modification at the BDNF gene in the hippocampus of mice. Exposure to an enriched environment for 3–4 weeks caused a dramatic increase in the mRNA expression of BDNF, but not platelet‐derived growth factor A (PDGF‐A), PDGF… 
Exercise impacts brain‐derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation
Exercise stimulates DNA demethylation in Bdnf promoter IV, and elevates levels of activated methyl‐CpG‐binding protein 2, as well as BDNF mRNA and protein in the rat hippocampus, and emphasizes the importance of exercise on the control of gene transcription in the context of brain function and plasticity.
Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats
The findings of this study elucidated the epigenetic mechanism underlying memory deficiency induced by neonatal anesthesia and propose EE as a potential therapeutic approach.
Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment.
EE improved cognitive function, and increased the proliferation, differentiation and survival of newly‑formed neurons in the DG of adult rats; however, EE did not activate neurogenesis in the SVZ, which provides a theoretical basis to explain the beneficial effects of EE on healthy, adult rats.
Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor κB-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning
It is demonstrated that aged rats respond to a belated period of EE by increasing hippocampal plasticity, together with activating sustained acetylation-associated mechanisms recruiting NF-κB and promoting related gene transcription that are likely to trigger beneficial effects associated with EE during aging.
Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV
It is demonstrated that enriched environment (EE) treatment rescued depression-like behavior, decreased BDNF levels and defective neurogenesis in the HIP caused by lack of promoter IV-driven BDNF expression, suggesting thatBDNF levels may be one of the key factors regulating depression and antidepressant effects through hippocampal neurogenisation.
Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits
Results suggest that histone lysine methylation levels are abnormally regulated in the aged hippocampus and identify hist one lysines methylation as a transcriptional mechanism by which EE may serve to restore memory formation with aging.
Role of BDNF epigenetics in activity-dependent neuronal plasticity
  • N. Karpova
  • Biology, Psychology
  • 2014
Environmental Enrichment Effects on the Brain-Derived Neurotrophic Factor Expression in Healthy Condition, Alzheimer's Disease, and Other Neurodegenerative Disorders.
The potential of BDNF regulation in coping with neurodegenerative processes characterizing Alzheimer's disease (AD), given BDNF expression alterations are described in AD patients is analyzed, by taking into account both changes in protein expression and regulation of gene expression.


Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment
It is concluded that BDNF but not NT‐4 is required for the environmental induction of neurogenesis, and failure to up‐regulate BDNF accompanied the lack of a neurogenic response in enriched BDNF heterozygous mice.
Mouse and rat BDNF gene structure and expression revisited
It is shown that kainic acid‐induced seizures that lead to changes in cellular Ca2+ levels as well as inhibition of DNA methylation and histone deacetylation contribute to the differential regulation of the expression of BDNF transcripts.
Multiple promoters direct tissue-specific expression of the rat BDNF gene
BDNF enhances the differentiation but not the survival of CNS stem cell- derived neuronal precursors
It is suggested that BDNF markedly enhances the antigenic and morphologic differentiation of EGF-generated neuronal precursors and is not sufficient for preventing their death over time.
Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain
Findings from this study may be useful for elucidating the in vivo role of growth factors in neurogenesis in the adult CNS and may aid development of neuronal replacement strategies after brain damage.
Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone.
BDNF supports the survival of neurons produced by the adult rat forebrain and may act as a permissive factor for neuronal recruitment in adulthood.
Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory.
It is shown that adult rats housed in an enriched environment show improved performance in a spatial learning test, suggesting that environmental cues can enhance neurogenesis in the adult hippocampal region, which is associated with improved spatial memory.