Hippocampal epigenetic modification at the brain‐derived neurotrophic factor gene induced by an enriched environment

@article{Kuzumaki2011HippocampalEM,
  title={Hippocampal epigenetic modification at the brain‐derived neurotrophic factor gene induced by an enriched environment},
  author={Naoko Kuzumaki and Daigo Ikegami and Rie Tamura and Nana Hareyama and Satoshi Imai and Michiko Narita and Kazuhiro Torigoe and Keiichi Niikura and Hideyuki Takeshima and Takayuki Ando and Katsuhide Igarashi and Jun Kanno and Toshikazu Ushijima and Tsutomu Suzuki and Minoru Narita},
  journal={Hippocampus},
  year={2011},
  volume={21}
}
Environmental enrichment is an experimental paradigm that increases brain‐derived neurotrophic factor (BDNF) gene expression accompanied by neurogenesis in the hippocampus of rodents. In the present study, we investigated whether an enriched environment could cause epigenetic modification at the BDNF gene in the hippocampus of mice. Exposure to an enriched environment for 3–4 weeks caused a dramatic increase in the mRNA expression of BDNF, but not platelet‐derived growth factor A (PDGF‐A), PDGF… 
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Role of BDNF epigenetics in activity-dependent neuronal plasticity
  • N. Karpova
  • Biology, Psychology
    Neuropharmacology
  • 2014
Environmental Enrichment Effects on the Brain-Derived Neurotrophic Factor Expression in Healthy Condition, Alzheimer's Disease, and Other Neurodegenerative Disorders.
TLDR
The potential of BDNF regulation in coping with neurodegenerative processes characterizing Alzheimer's disease (AD), given BDNF expression alterations are described in AD patients is analyzed, by taking into account both changes in protein expression and regulation of gene expression.
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