Hippocampal ensemble dynamics timestamp events in long-term memory

  title={Hippocampal ensemble dynamics timestamp events in long-term memory},
  author={Alon Rubin and Nitzan Geva and Liron Sheintuch and Yaniv Ziv and Howard Eichenbaum},
The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms. We performed time-lapse imaging of thousands of neurons over weeks in the hippocampal CA1 of mice as they repeatedly visited two distinct environments. Longitudinal analysis exposed ongoing environment-independent evolution of episodic representations, despite stable place field locations and constant remapping between the two… CONTINUE READING