Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation.

@article{Lin2011HippocampalEP,
  title={Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation.},
  author={Qing-Shu Lin and Qian Yang and Dan-Dan Liu and Zhe Sun and Hao Dang and Juan Liang and Y Wang and Jieyan Chen and Sheng-tian Li},
  journal={Brain research bulletin},
  year={2011},
  volume={86 3-4},
  pages={139-45}
}
Recent studies show contradictory results regarding the contribution of endocannabinoids in fear memory formation and long-term synaptic plasticity. In this study, we investigated the effects of both cannabinoid receptor type 1 (CB1 receptor) antagonist AM281 and anandamide reuptake inhibitor AM404 on the formation of contextual fear memory in adult mice… CONTINUE READING