Hippocampal drebrin loss in mild cognitive impairment.

  title={Hippocampal drebrin loss in mild cognitive impairment.},
  author={Scott Counts and Bin He and Muhammad Nadeem and Joanne Wuu and Stephen William Scheff and Elliott J. Mufson},
  journal={Neuro-degenerative diseases},
  volume={10 1-4},
Alterations in the relative abundance of synaptic proteins may contribute to hippocampal synaptic dysfunction in Alzheimer's disease (AD). The extent to which perturbations in synaptic protein expression occur during the earliest stages of cognitive decline remains unclear. We examined protein levels of presynaptic synaptophysin (SYP) and synaptotagmin (SYT), and postsynaptic drebrin (DRB), a marker for dendritic spine plasticity, in the hippocampus of people with an antemortem clinical… CONTINUE READING