Hippocampal damage after intra-amygdala kainic acid-induced status epilepticus and seizure preconditioning-mediated neuroprotection in SJL mice.

@article{Tanaka2010HippocampalDA,
  title={Hippocampal damage after intra-amygdala kainic acid-induced status epilepticus and seizure preconditioning-mediated neuroprotection in SJL mice.},
  author={Katsuhiro Tanaka and Eva M. Jim{\'e}nez-Mateos and Satoshi Matsushima and Waro Taki and David C. Henshall},
  journal={Epilepsy research},
  year={2010},
  volume={88 2-3},
  pages={151-61}
}
Exposure of the brain to a stressful stimulus that is sub-threshold for permanent injury can temporarily protect against cell death during a subsequent and otherwise damaging insult. One or more brief, non-harmful seizure episode(s) (seizure preconditioning) can dramatically reduce hippocampal damage when given prior to status epilepticus (epileptic tolerance). We recently reported that status epilepticus-induced hippocampal damage in C57BL/6 mice could be reduced by approximately 50% when… CONTINUE READING
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