Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model.

@article{Samuel1994HippocampalCA,
  title={Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model.},
  author={Wedderburn. Samuel and Eliezer Masliah and L. Robert Hill and Nelson M. Butters and Robert D. Terry},
  journal={Neurology},
  year={1994},
  volume={44 11},
  pages={
          2081-8
        }
}
Our prior research on patients with Alzheimer's disease (AD) found a high correspondence between premortem dementia and accumulation of neurofibrillary tangles (NFTs) with concurrent loss of synapse density in several brain regions. In the present study, we examined these same clinicopathologic relationships in the context of seven subregions of the hippocampal formation using a sample of 16 AD patients who had been administered three well-known mental status tests antemortem. We found NFT… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

Similar Papers

Loading similar papers…