Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder

@article{Dias2014HippocampalBO,
  title={Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder},
  author={Gisele Pereira Dias and M. C. N. Bevilaqua and Anna Claudia Domingos Silveira da Luz and Renata Lopes Fleming and Patr{\'i}cia Franca Gardino},
  journal={Behavioural Brain Research},
  year={2014},
  volume={263},
  pages={34-45}
}
Generalized anxiety disorder (GAD) is highly prevalent and incapacitating. Here we used the Carioca High-Conditioned Freezing (CHF) rats, a previously validated animal model for GAD, to identify biomarkers and structural changes in the hippocampus that could be part of the underlying mechanisms of their high-anxiety profile. Spatial and fear memory was assessed in the Morris water maze and passive avoidance test. Serum corticosterone levels, immunofluorescence for glucocorticoid receptors (GR… CONTINUE READING
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