Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy.

@article{OBrien1997HippocampalAI,
  title={Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy.},
  author={Terence J. O'Brien and Mark R. Newton and Mark J. Cook and Salvatore Ugo Berlangieri and C. William Kilpatrick and Kenneth A Morris and Samuel F. Berkovic},
  journal={Epilepsia},
  year={1997},
  volume={38 1},
  pages={74-80}
}
PURPOSE The pathophysiologic basis for the [18F]fluorodeoxyglucose positron-emission tomography (FDG-PET) temporal lobe hypometabolism in patients with hippocampal sclerosis (HS) is uncertain. We tested the hypothesis that hippocampal atrophy, which is strongly correlated with hippocampal cell loss, is largely responsible for the regional hypometabolism in HS. METHODS Regions of interest (ROIs) on FDG-PET scanning were determined in the medial, lateral, and posterior temporal lobe, thalamus… CONTINUE READING

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