Hippocampal and neocortical ubiquitin-immunoreactive inclusions in amyotrophic lateral sclerosis with dementia.

@article{Wightman1992HippocampalAN,
  title={Hippocampal and neocortical ubiquitin-immunoreactive inclusions in amyotrophic lateral sclerosis with dementia.},
  author={G Wightman and Valerie E Anderson and Joanne Elizabeth Martin and Michael Swash and Brian H. Anderton and David Neary and David N Mann and Philip J. Luthert and Peter Nigel Leigh},
  journal={Neuroscience letters},
  year={1992},
  volume={139 2},
  pages={269-74}
}
Amyotrophic lateral sclerosis (ALS) patients with dementia were found to have ubiquitin-immunoreactive (IR) inclusions in the dentate granule cells of the hippocampus. These inclusions were also present in some patients with minor cognitive changes but otherwise typical ALS. Ubiquitin-IR inclusions were also found in neurons of superficial layers of the frontal and temporal cortex and in the entorhinal cortex in patients with ALS and dementia. These ubiquitin-IR inclusions were non-argyrophilic… CONTINUE READING