Hippocampal and amygdala volumes in children and adults with childhood maltreatment‐related posttraumatic stress disorder: A meta‐analysis

  title={Hippocampal and amygdala volumes in children and adults with childhood maltreatment‐related posttraumatic stress disorder: A meta‐analysis},
  author={Fu Lye M Woon and Dawson W. Hedges},
Little work has directly examined the course of hippocampal volume in children and adults with childhood maltreatment‐related posttraumatic stress disorder (PTSD). Data from adults suggest that hippocampal volume deficits are associated with PTSD, whereas findings from children with PTSD generally show no hippocampal volume deficits in PTSD. Additionally, the role of the amygdala in emotional response makes it a possible region for investigation in children and adults with childhood… 

Gender does not moderate hippocampal volume deficits in adults with posttraumatic stress disorder: A meta‐analysis

Hippocampal volumes were significantly smaller in the PTSD group compared to the control group, but gender did not significantly moderate any effect sizes in the meta‐regression or subgroup analyses, which suggests that hippocampal volume deficits in PTSD are independent of gender.

Evidence for smaller right amygdala volumes in posttraumatic stress disorder following childhood trauma

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Timing of traumatization was associated with amygdala volumes throughout the lifespan, with opposite effects dependent on age at trauma occurrence, as well as potential confounders like trauma-type and multiplicity.

Beating the brain about abuse: Empirical and meta-analytic studies of the association between maltreatment and hippocampal volume across childhood and adolescence

The results of the meta-analysis confirmed that experiences of childhood malt treatment are associated with a reduction in hippocampal volume and that the effects of maltreatment are more pronounced when the maltreatment occurs in middle childhood compared to early childhood or adolescence.

Abnormal hippocampal morphology in dissociative identity disorder and post‐traumatic stress disorder correlates with childhood trauma and dissociative symptoms

Findings support a childhood trauma‐related etiology for abnormal hippocampal morphology in both PTSD and DID and can further the understanding of neurobiological mechanisms involved in these disorders.

Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress

Novel evidence is provided that reductions in corticolimbic gray matter, particularly within the hippocampus and medial prefrontal cortex, are associated with reported childhood maltreatment and individual differences in adult trait anxiety and suggest that these structural alterations contribute to increased affective sensitivity to stress later in life in those that have experienced early adversity.

Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions.




Stress Predicts Brain Changes in Children: A Pilot Longitudinal Study on Youth Stress, Posttraumatic Stress Disorder, and the Hippocampus

Results from this pilot study suggest that stress is associated with hippocampal reduction in children with posttraumatic stress disorder symptoms and provide preliminary human evidence that stress may indeed damage the hippocampus.

MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder.

The results of this study are consistent with deficits in hippocampal function and structure in abuse-related PTSD.

Bilateral hippocampal volume reduction in adults with post‐traumatic stress disorder: A meta‐analysis of structural MRI studies

Volume differences are consistent with the notion that exposure to stressful experiences can lead to hippocampal atrophy, although prospective studies would be necessary to unambiguously establish such a relationship.

Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD.

Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder.