Hippocampal and amygdala volumes in children and adults with childhood maltreatment‐related posttraumatic stress disorder: A meta‐analysis

@article{Woon2008HippocampalAA,
  title={Hippocampal and amygdala volumes in children and adults with childhood maltreatment‐related posttraumatic stress disorder: A meta‐analysis},
  author={Fu Lye M Woon and Dawson W. Hedges},
  journal={Hippocampus},
  year={2008},
  volume={18}
}
Little work has directly examined the course of hippocampal volume in children and adults with childhood maltreatment‐related posttraumatic stress disorder (PTSD). Data from adults suggest that hippocampal volume deficits are associated with PTSD, whereas findings from children with PTSD generally show no hippocampal volume deficits in PTSD. Additionally, the role of the amygdala in emotional response makes it a possible region for investigation in children and adults with childhood… 

Gender does not moderate hippocampal volume deficits in adults with posttraumatic stress disorder: A meta‐analysis

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The results of the meta-analysis confirmed that experiences of childhood malt treatment are associated with a reduction in hippocampal volume and that the effects of maltreatment are more pronounced when the maltreatment occurs in middle childhood compared to early childhood or adolescence.

Abnormal hippocampal morphology in dissociative identity disorder and post‐traumatic stress disorder correlates with childhood trauma and dissociative symptoms

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Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress

Novel evidence is provided that reductions in corticolimbic gray matter, particularly within the hippocampus and medial prefrontal cortex, are associated with reported childhood maltreatment and individual differences in adult trait anxiety and suggest that these structural alterations contribute to increased affective sensitivity to stress later in life in those that have experienced early adversity.

Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions.

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