Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes

@article{Alfini2016HippocampalAC,
  title={Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes},
  author={A. Alfini and L. Weiss and Brooks P Leitner and Theresa J. Smith and J. Hagberg and J. Smith},
  journal={Frontiers in Aging Neuroscience},
  year={2016},
  volume={8}
}
While endurance exercise training improves cerebrovascular health and has neurotrophic effects within the hippocampus, the effects of stopping this exercise on the brain remain unclear. Our aim was to measure the effects of 10 days of detraining on resting cerebral blood flow (rCBF) in gray matter and the hippocampus in healthy and physically fit older adults. We hypothesized that rCBF would decrease in the hippocampus after a 10-day cessation of exercise training. Twelve master athletes… Expand
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References

SHOWING 1-10 OF 72 REFERENCES
Impact of a Single Bout of Aerobic Exercise on Regional Brain Perfusion and Activation Responses in Healthy Young Adults
TLDR
Preliminary evidence of regionalized brain effects associated with a single bout of aerobic exercise is provided to provide some insight into the brain’s ability to change in relation to chronic interventions. Expand
Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging
TLDR
Cognitive gains were manifested in the exercise group's improved immediate and delayed memory performance from T1 to T3 which also showed a significant positive association with increases in both left and right hippocampal CBF identified earlier in the time course at T2. Expand
Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys
TLDR
It is indicated that the level of exercise associated with improved fitness in middle-aged humans is sufficient to increase both the rate of learning and blood flow to the cerebral cortex, at least during the period of regular exercise. Expand
Plasticity of Brain Networks in a Randomized Intervention Trial of Exercise Training in Older Adults
TLDR
This study provides the first evidence for exercise-induced functional plasticity in large-scale brain systems in the aging brain, using functional connectivity techniques, and offers new insight into the role of aerobic fitness in attenuating age-related brain dysfunction. Expand
Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat
TLDR
Data indicate that capillary growth occurs in motor areas of the cerebral cortex as a robust adaptation to prolonged motor activity and the vascular system also experiences heightened flow under conditions of activation. Expand
Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: Implications for fMRI
TLDR
Findings suggest changes in human cerebral blood flow that result from acute moderate intensity exercise can be detected afterwards using PASL at 3T with an inversion time of 1,575 ms, and suggests future use of indices of functional activation should account for exercise-induced changes in cardio-pulmonary physiology and CBF. Expand
Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial
TLDR
Aerobic training significantly increased hippocampal volume in older women with probable MCI, and was independently associated with reduced verbal memory and learning performance as indexed by loss after interference. Expand
Semantic memory functional MRI and cognitive function after exercise intervention in mild cognitive impairment.
TLDR
Exercise may improve neural efficiency during semantic memory retrieval in MCI and cognitively intact older adults, and may lead to improvement in cognitive function. Expand
Aerobic fitness is associated with hippocampal volume in elderly humans
TLDR
Investigating whether individuals with higher levels of aerobic fitness displayed greater volume of the hippocampus and better spatial memory performance than individuals with lower fitness levels found a triple association such that higher fitness levels were associated with larger left and right hippocampi after controlling for age, sex, and years of education. Expand
Effects of detraining on cardiovascular responses to exercise: role of blood volume.
TLDR
The findings indicate that the decline in cardiovascular function following a few weeks of detraining is largely due to a reduction in blood volume, which appears to limit ventricular filling during upright exercise. Expand
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