Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding.

@article{Kircher2007HippocampalAI,
  title={Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding.},
  author={Tilo Kircher and Susanne Weis and Katrin Freymann and Michael Erb and Frank Jessen and Wolfgang Grodd and Reinhard Heun and Dirk T. Leube},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2007},
  volume={78 8},
  pages={812-8}
}
BACKGROUND Episodic memory enables us to consciously recollect personally experienced past events. Memory performance is reduced in patients with mild cognitive impairment (MCI), an at-risk condition for Alzheimer's disease (AD). PATIENTS AND METHODS We used functional MRI (fMRI) to compare brain activity during memory encoding in 29 healthy elderly subjects (mean age 67.7 (SD 5.4) years) and 21 patients with MCI (mean age 69.7 (SD 7.0) years). Subjects remembered a list of words while fMRI… CONTINUE READING