Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose.

@article{Ragozzino1996HippocampalAR,
  title={Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose.},
  author={Michael E. Ragozzino and K E Unick and Paul E Gold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 10},
  pages={4693-8}
}
Several lines of evidence indicate that a modest increase in circulating glucose levels enhances memory. One mechanism underlying glucose effects on memory may be an increase in acetylcholine (ACh) release. The present experiment determined whether enhancement of spontaneous alternation performance by systemic glucose treatment is related to an increase in hippocampal ACh output. Samples of extracellular ACh were assessed at 12-min intervals using in vivo microdialysis with HPLC-EC. Twenty-four… CONTINUE READING

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