Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.

@article{Hall2014HippocampalLP,
  title={Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.},
  author={H{\'e}l{\`e}ne Hall and Stefanie Reyes and Natalie Landeck and Chris R Bye and Giampiero Leanza and Kay L Double and Lachlan Thompson and Glenda M Halliday and Deniz Kirik},
  journal={Brain : a journal of neurology},
  year={2014},
  volume={137 Pt 9},
  pages={
          2493-508
        }
}
The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic and cholinergic regulatory projection systems degenerate, but the exact pathways that may explain the development of dementia in patients with Parkinson's disease remain unclear… CONTINUE READING
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Movement disorders : official journal of the Movement Disorder Society • 2012
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