Hippocampal Focal Knockout of CBP Affects Specific Histone Modifications, Long-Term Potentiation, and Long-Term Memory

@article{Barrett2011HippocampalFK,
  title={Hippocampal Focal Knockout of CBP Affects Specific Histone Modifications, Long-Term Potentiation, and Long-Term Memory},
  author={Ruth M. Barrett and Melissa Malvaez and Eniko A. Kram{\'a}r and Dina P Matheos and Abraham Arrizon and S. C. Motta Cabrera and Gary Lynch and Robert W Greene and Marcelo Wood},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={1545-1556}
}
To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in neurons of the CA1 region of the hippocampus during memory formation, we examine the effects of a focal homozygous knockout of CBP on histone modifications, gene expression, synaptic plasticity, and long-term memory. We show that CBP is critical for the in vivo acetylation of lysines on histones H2B, H3, and H4. CBP's homolog p300 was unable to compensate for the loss of CBP. Neurons lacking CBP maintained… CONTINUE READING
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