Hippocampal Cytogenesis Correlates to Escitalopram-Mediated Recovery in a Chronic Mild Stress Rat Model of Depression

@article{Jayatissa2006HippocampalCC,
  title={Hippocampal Cytogenesis Correlates to Escitalopram-Mediated Recovery in a Chronic Mild Stress Rat Model of Depression},
  author={Magdalena Niepsuj Jayatissa and Christina F. Bisgaard and Anders Tingstr{\"o}m and Mariusz Papp and Ove Wiborg},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={2395-2404}
}
From clinical studies it is known that recurrent depressive episodes associate with a reduced hippocampal volume. Conversely, preclinical studies have shown that chronic antidepressant treatment increases hippocampal neurogenesis. Consequently, it has been suggested that a deficit in hippocampal neurogenesis is implicated in the pathophysiology of depression. To study a potential correlation between recovery and hippocampal cytogenesis, we established the chronic mild stress (CMS) rat model of… CONTINUE READING
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