Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice

@inproceedings{Lin2017HippocampalCK,
  title={Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice},
  author={Jing-ran Lin and Shun-chang Fang and Susu Tang and Mei Long Hu and Yan Long and Arijit Ghosh and Hongbin Sun and Ling-yi Kong and Hao Hong},
  booktitle={Acta Pharmacologica Sinica},
  year={2017}
}
Evidence suggests that neuroinflammation is involved in depression and that the cysteinyl leukotriene receptor 1 (CysLT1R) plays a potential pathophysiological role in several types of CNS disorders. Our previous study has shown that knockdown of hippocampal CysLT1R in mice prevents the depressive-like phenotype and neuroinflammation induced by chronic mild stress (CMS). Here, we examined the effects of hippocampal CysLT1R knockdown and CysLT1R blockade on LPS-induced depressive-like behavior… CONTINUE READING
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