Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments

  title={Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments},
  author={J. J. Brightwell and M. Gallagher and P. Colombo},
  journal={Neurobiology of Learning and Memory},
  • J. J. Brightwell, M. Gallagher, P. Colombo
  • Published 2004
  • Psychology, Medicine
  • Neurobiology of Learning and Memory
  • Recent evidence has shown that abnormal signal transduction is related to non-pathological memory impairment among aged subjects. Members of the CREB family of transcription factors contain enhancers (i.e., CREB1) and repressors (i.e., CREB2) of transcription and interact with numerous signaling proteins to mediate the transition from short-term to long-term memory. In this study, quantitative Western blotting was used to determine the levels of CREB1 and CREB2 in homogenates from hippocampi of… CONTINUE READING

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