Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats.

@article{Frye2004Hippocampal3M,
  title={Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats.},
  author={Cheryl Anne Frye and Alicia A. Walf},
  journal={Pharmacology, biochemistry, and behavior},
  year={2004},
  volume={78 3},
  pages={531-40}
}
The 5alpha-reduced metabolite of progesterone (P), 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), may mediate progestins' effects to reduce depressive behavior of female rats in part through actions in the hippocampus. To investigate, forced swim test behavior and plasma and hippocampal progestin levels were assessed in groups of rats expected to differ in their 3alpha,5alpha-THP levels due to endogenous differences (pregnant and postpartum), administration of a 5alpha-reductase inhibitor… CONTINUE READING

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