Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory.

@article{Kobayashi2005HippocalcindeficientMD,
  title={Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory.},
  author={Masaaki Kobayashi and Tamotsu Masaki and Kei Hori and Yoshinori Masuo and Masaomi Miyamoto and Hiroshi Tsubokawa and Hideyo Noguchi and Masayoshi Nomura and Ken Takamatsu},
  journal={Neuroscience},
  year={2005},
  volume={133 2},
  pages={
          471-84
        }
}
Hippocalcin is a member of the neuronal calcium sensor (NCS) protein family that is highly expressed in hippocampal pyramidal cells and moderately expressed in the neurons of cerebral cortex, cerebellum and striatum. Here we examined the physiological roles of hippocalcin using targeted gene disruption. Hippocalcin-deficient (-/-) mice displayed no obvious structural abnormalities in the brain including hippocampal formation at the light microscopic level. Deletion of hippocalcin did not result… CONTINUE READING

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