Hippo signalling: liver size regulation and beyond.

  title={Hippo signalling: liver size regulation and beyond.},
  author={Thierry Tordjmann},
  journal={Clinics and research in hepatology and gastroenterology},
  volume={35 5},
After its discovery in Drosophila, the Hippo signalling pathway has been shown to regulate organ size in mammals as well. Based on recent studies, this kinase cascade appears in particular crucial for liver tissue homeostasis, by regulating both cellular proliferation and apoptosis. Thereby, Hippo signalling may appear as a key pathway in liver carcinogenesis.