Hippo signaling promotes JNK-dependent cell migration

  title={Hippo signaling promotes JNK-dependent cell migration},
  author={Xianjue Ma and H. Wang and J. Ji and Wenyan Xu and Y. Sun and W. Li and X. Zhang and J. Chen and L. Xue},
  journal={Proceedings of the National Academy of Sciences},
  pages={1934 - 1939}
  • Xianjue Ma, H. Wang, +6 authors L. Xue
  • Published 2017
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance Cancer is the leading cause of death worldwide, although studies revealed that dysregulation of the Hippo pathway contributes to tumorigenesis, whereas its roles in tumor invasion and cell migration remain paradoxical and largely elusive. Using Drosophila as a model, we herein find cross-talk between the Hippo and JNK pathways in regulating cell migration and invasion. Mechanistically, we identify bantam-Rox8 modules as essential components downstream of Yorkie in mediating JNK… CONTINUE READING
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