Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.

@article{Lu2010HippoSI,
  title={Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.},
  author={Li Lu and Ying Li and Soo Mi Kim and Wouter Bossuyt and Pu Liu and Qiong Qiu and Yingdi Wang and Georg Halder and Milton J. Finegold and Ju-Seog Lee and Randy L Johnson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 4},
  pages={
          1437-42
        }
}
How organ size is controlled in mammals is not currently understood. In Drosophila the Hippo signaling pathway functions to suppress growth in imaginal discs and has been suggested to control organ size. To investigate the role of hippo signaling in regulation of mammalian organ size we have generated conditional alleles of Sav1, mst1, and mst2, orthologs of Drosophila Salvador and hippo, respectively. Specific deletion of both mst1 and mst2 in hepatocytes results in significantly enlarged… CONTINUE READING

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