Hippo signaling in organ size control.

  title={Hippo signaling in organ size control.},
  author={Duojia Pan},
  journal={Genes & development},
  volume={21 8},
The control of organ (or organism) size is a fundamental aspect of life that has long captured human imagination. What makes an elephant grow a million times larger than a mouse? How do our two hands develop independently of each other yet reach very similar size? How does a liver precisely regenerate its original mass when two-thirds of it is removed? The recent discovery of a novel signaling network in Drosophila, known as the Hippo (Hpo) pathway, might provide an important entry point to… CONTINUE READING
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