Hippo pathway regulation of gastrointestinal tissues.

  title={Hippo pathway regulation of gastrointestinal tissues.},
  author={Fa-xing Yu and Zhipeng Meng and Steven W. Plouffe and Kun Liang Guan},
  journal={Annual review of physiology},
The Hippo pathway plays a crucial role in regulating tissue homeostasis and organ size, and its deregulation is frequently observed in human cancer. Yap is the major effector of and is inhibited by the Hippo pathway. In mouse model studies, inducible Yap expression in multiple tissues results in organ overgrowth. In the liver, knockout of upstream Hippo pathway components or transgenic expression of Yap leads to liver enlargement and hepatocellular carcinoma. In the small intestine or colon… CONTINUE READING
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