Hippo pathway mediates resistance to cytotoxic drugs

  title={Hippo pathway mediates resistance to cytotoxic drugs},
  author={Taranjit S. Gujrala and Marc W. Kirschnera},
  • Taranjit S. Gujrala, Marc W. Kirschnera
  • Published 2017
Chemotherapy is widely used for cancer treatment, but its effectiveness is limited by drug resistance. Here, we report a mechanism by which cell density activates the Hippo pathway, which in turn inactivates YAP, leading to changes in the regulation of genes that control the intracellular concentrations of gemcitabine and several other US Food and Drug Administration (FDA)-approved oncology drugs. Hippo inactivation sensitizes a diverse panel of cell lines and human tumors to gemcitabine in 3D… CONTINUE READING