Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*

  title={Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*},
  author={S. W. Chan and C. J. Lim and Y. F. Chong and A. Pobbati and Caixia Huang and W. Hong},
  journal={The Journal of Biological Chemistry},
  pages={7018 - 7026}
  • S. W. Chan, C. J. Lim, +3 authors W. Hong
  • Published 2011
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In this report, we describe an independent mechanism for the cell to restrict the activity of TAZ and YAP through interaction with angiomotin (Amot) and angiomotin-like 1 (AmotL1). Amot and AmotL1 were robustly co-immunoprecipitated with FLAG-tagged TAZ, and their interaction is dependent on the WW domain of TAZ and the PPXY motif in the N… CONTINUE READING
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