Hippo Pathway Activity Influences Liver Cell Fate

  title={Hippo Pathway Activity Influences Liver Cell Fate},
  author={Dean Yimlamai and Constantina Christodoulou and Giorgio Giacomo Galli and Kilangsungla Yanger and Brian Pepe-Mooney and Basanta Gurung and Kriti Shrestha and Patrick Cahan and Ben Z. Stanger and Fernando D Camargo},
The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity is essential for the maintenance of the differentiated hepatocyte state. Remarkably, acute inactivation of Hippo pathway signaling in vivo is sufficient to dedifferentiate, at very… CONTINUE READING
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