Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.

  title={Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.},
  author={Karel Vali{\vs} and Lubom{\'i}r Proch{\'a}zka and Evzen Boura and Jaromira Chladova and Tom{\'a}{\vs} Ob{\vs}il and Jakub Rohlena and Jaroslav Truksa and L Dong and Stephen John Ralph and Jiri Neuzil},
  journal={Cancer research},
  volume={71 3},
The proapoptotic protein Noxa, a member of the BH3-only Bcl-2 protein family, can effectively induce apoptosis in cancer cells, although the relevant regulatory pathways have been obscure. Previous studies of the cytotoxic effects of α-tocopheryl succinate (α-TOS) on cancer cells identified a mechanism whereby α-TOS caused apoptosis requiring the Noxa-Bak axis. In the present study, ab initio analysis revealed a conserved FoxO-binding site (DBE; DAF-16 binding element) in the NOXA promoter, and… CONTINUE READING
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Mitochondria play a central role in apoptosis induced by atocopheryl succinate, an agent with anticancer activity. Comparison with receptor-mediated pro-apoptotic signaling

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