Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.

@article{Sutton2013Hip14ldeficientMD,
  title={Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.},
  author={Liza M. Sutton and Shaun S. Sanders and Stefanie L. Butland and Roshni R. Singaraja and Sonia Franciosi and Amber L. Southwell and Crystal N. Doty and Mandi E. Schmidt and Katherine K. N. Mui and Vlad Kovalik and Fiona B J Young and Weining Zhang and Michael R. Hayden},
  journal={Human molecular genetics},
  year={2013},
  volume={22 3},
  pages={452-65}
}
Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT) enzymes, modulates protein function and localization and plays a key role in the nervous system. Huntingtin-interacting protein 14 (HIP14), a well-characterized neuronal PAT, has been implicated in the… CONTINUE READING