Hinged Plakin Domains Provide Specialized Degrees of Articulation in Envoplakin, Periplakin and Desmoplakin

Abstract

Envoplakin, periplakin and desmoplakin are cytoskeletal proteins that provide structural integrity within the skin and heart by resisting shear forces. Here we reveal the nature of unique hinges within their plakin domains that provides divergent degrees of flexibility between rigid long and short arms composed of spectrin repeats. The range of mobility of… (More)
DOI: 10.1371/journal.pone.0069767

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Cite this paper

@inproceedings{AlJassar2013HingedPD, title={Hinged Plakin Domains Provide Specialized Degrees of Articulation in Envoplakin, Periplakin and Desmoplakin}, author={Caezar Al-Jassar and Pau Bernadό and Martyn A.J. Chidgey and Michael Overduin}, booktitle={PloS one}, year={2013} }