Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region.

@article{Marn2000HindbrainPF,
  title={Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region.},
  author={Faustino Mar{\'i}n and Patrick Charnay},
  journal={Development},
  year={2000},
  volume={127 22},
  pages={4925-35}
}
Krox20 and mafB/kr are regulatory genes involved in hindbrain segmentation and anteroposterior (AP) patterning. They are expressed in rhombomeres (r) r3/r5 and r5/r6 respectively, as well as in the r5/r6 neural crest. Since several members of the fibroblast growth factor (FGF) family are expressed in the otic/preotic region (r2-r6), we investigated their possible involvement in the regulation of Krox20 and mafB/kr. Application of exogenous FGFs to the neural tube of 4- to 7-somite chick embryos… CONTINUE READING