Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle.

@article{HutchinsWiese2012HindLS,
  title={Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle.},
  author={Heather L Hutchins-Wiese and Yong Li and Kevin R Hannon and Bruce A. Watkins},
  journal={The Journal of nutritional biochemistry},
  year={2012},
  volume={23 8},
  pages={986-93}
}
Muscle disuse has numerous physiological consequences that end up with significant catabolic metabolism and ultimately tissue atrophy. What is not known is how muscle atrophy affects the endocannabinoid (EC) system. Arachidonic acid (AA) is the substrate for anandamide (AEA) and 2-arachidonylgycerol (2-AG), which act as agonists for cannabinoid receptors CB1 and CB2 found in muscle. Diets with n-3 polyunsaturated fatty acids (PUFA) have been shown to reduce tissue levels of AA, AEA and 2-AG… CONTINUE READING
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