Hind-limb motor ability in Lewis rats during the onset and recovery phases of experimental autoimmune encephalomyelitis

@article{Simmons1981HindlimbMA,
  title={Hind-limb motor ability in Lewis rats during the onset and recovery phases of experimental autoimmune encephalomyelitis},
  author={Roger D. Simmons and Claude C. A. Bernard and Kim Teck Ng and P RASAD C HALASANI Carnegie},
  journal={Brain Research},
  year={1981},
  volume={215},
  pages={103-114}
}
Hind-limb motor function in adult female Lewis rats with experimental autoimmune encephalomyelitis (EAE) was investigated using an objective behavioral measurement of motor ability. Rats were pretrained to avoid falling from the external surface of a power-driven running wheel. The performance of EAE-group rats on the wheel was then compared with that of saline and adjuvant controls immediately prior to the onset of clinical signs of EAE, and within 3 days of apparent recovery from EAE. Results… CONTINUE READING