Hill-Robertson interference is a minor determinant of variations in codon bias across Drosophila melanogaster and Caenorhabditis elegans genomes.

@article{Marais2002HillRobertsonII,
  title={Hill-Robertson interference is a minor determinant of variations in codon bias across Drosophila melanogaster and Caenorhabditis elegans genomes.},
  author={Gabriel A. B. Marais and Gwena{\"e}l Piganeau},
  journal={Molecular biology and evolution},
  year={2002},
  volume={19 9},
  pages={1399-406}
}
According to population genetics models, genomic regions with lower crossing-over rates are expected to experience less effective selection because of Hill-Robertson interference (HRi). The effect of genetic linkage is thought to be particularly important for a selection of weak intensity such as selection affecting codon usage. Consistent with this model, codon bias correlates positively with recombination rate in Drosophila melanogaster and Caenorhabditis elegans. However, in these species… CONTINUE READING

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