Hill Coefficient Analysis of Transmembrane Helix Dimerization

Here, we employed the Hill equation, used broadly to characterize cooperativity in protein–ligand binding, to describe the dimerization of transmembrane (TM) helices in hydrophobic environments. The Hill analysis of wild-type fibroblast growth factor receptor 3 (FGFR3) TM domain dimerization gives a Hill coefficient of ~1 for lipid bilayers but only ~0.2… CONTINUE READING